So I've been researching DOD, and I think the best currently available solution for a cam would be a custom grind with the same lift, maybe a little more, and more duration. You could then move the LDA smaller to get the thing to lope or spread it out to keep the same fuel economy and braking performance. A little bit stiffer spring would be necessary to keep the valves from floating, but that shouldn't harm the lifters.
The LS6 heads on this beast are fine, and good for 400HP on the 6.0L, so I'm thinking a port and polish is a better route than aftermarket heads. And cheaper.
That leaves the intake, which is the weak sister in this whole thing. I looked past the throttle body, and I saw a very large obstruction. A little digging, and it seems this lump has to do with the oiling system of the DOD. So I'm thinking that the throttle body needs to be moved up, which would leave a larger plenum. Problem is, the torque minded intake runners are on the top of this thing. I found a stock replacement intake for $120, and since it is plastic I may buy one when I finish paying off my 17's and Dunlop Graspic snow tires (they weren't lying when they said the tires aren't any good below 40 degrees...) and try my hand making a custom intake using some tubing and fiber glass. Hopefully someone makes an aftermarket intake before I embarrass myself and ruin a perfectly good intake manifold...
Yeah Panther, this is my daily driver and I love driving it daily and terrorizing highway on ramps. 20.4 MPG lifetime fuel economy. My old Buick Ultra only got 18 MPG and I drove it the same way, at least in a straight line.