I'll tell you what Ive noticed over the last few years and I have now done this on three vehicles (getting ready to do a fourth on the Rodeo).
First, most people do not track their fuel mileage very well. Most of the time, and Im talking about 80%, people use guestimations about fuel economy. I see VERY few people that take the time to write down the trip odometer and main odometer readings and how much gas they pumped. I personally use my check card each time I gas up so that it has the cost, gallons and so on on the receipt print out and I write on it the odometer and trip odometer reading and I reset the trip odometer EVERY tank. I see very very few people take the time to record such information on their receipt or in some sort of fuel mileage log. Therefore they have little idea how far on a tank of gas they can go, or what kind of mileage they get.
Second, nearly everyone fills their tank up until the handle clicks off. And there is SO much variance in that it isnt even funny. I fill my tank up until it will take no more. As a result I have very accurate fuel mileage history.
Now, what I have done on my last three vehicles that has ALWAYS gained me mileage is upgraded the wiring. Starter, grounds, etc. My last vehicle gained me right at 2.5 mpg alone in doing that. With the Grand Prix I had a very long thread on ClubGP about the result of installing the voltage booster and the mileage I gained. I want to say it was close to 3 mpg if not a little more. I posted 4 tanks prior to installing the booster and 4 tanks after I believe it was.
So I have become a big proponent of upgrading the wiring and doing what you can to increase system voltage on a vehicle within reason. Obviously there is a point in which you can increase it too much and cause issues with electronics. My Grand Prix had a running voltage of about 14.5 volts or so, maybe a little closer to 15.
Let me give you a little math. Lets say your ignition coils are a 3100 to 1 ratio. That means for every turn on the coil on the primary side, the secondary has 3100 turns. Put 12 vdc to the primary, you get a little over 37000 volts out the secondary, to the plugs. Put 14 volts to the primary and you get 43000 or so volts out the secondary, which is dang near what after market coils put out.
Anyone want to guess what kind of effect that has?
Wire has resistance, maybe small amounts, but the larger the current output the more important that becomes and you can dang well bet that with something like the alternator and starter that resistance becomes important.